Biosynthesis of silver nanoparticles from Teucrioside and investigation of its antibacterial activity

Teucrioside, 9′-decarboxyrosmarinic acid 4′-O-α-rhamnosyl-(1‴→6‴)-O-β-galactosyl-(1‴→4″)-Oα-rhamnoside is a natural phenolic compound. It has been isolated and identified from the genus Teucrium. Teucrium widely used in traditional medicine for its antioxidant, diuretic, antiulcer, antitumor, anti-inflammatory, antispasmodic antibacterial properties. Since silver nanoparticles have superior physicochemical properties, they an important role biology medicine. In this study, biosynthesis of was carried out using Teucrioside AgNO3. The effect five independent variables (pH, AgNO3 concentration, volume/total volume, microwave power time) on nanoparticle formation evaluated central composite design (CCD) based response surface methodology (RSM). Nanoparticle demonstrated by UV-Vis spectroscopy FTIR analysis. particle size zeta potential were determined dynamic light scattering method (DLS). results showed that 5 mM AgNO3, volume:0.3, 475 watt, 60 sec. pH:7.5 optimal reaction parameters. activity biosynthesized tested against common pathogens such as Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumonia. Obtained great new agent.